The press service of St. Petersburg State University (SPbSU) reported that university researchers have discovered a compensatory mechanism that is activated in the brain in case of disorders of the dopamine system. The work was carried out on the DAT‑KO line of genetically modified rats with the dopamine transporter gene turned off.
Experiments have shown that when dopamine transport is impaired, the expression of the tyrosine hydroxylase gene, a key enzyme in the synthesis of this neurotransmitter, increases. This reaction looks like an attempt by the body to partially compensate for the deficiency characteristic of conditions such as ADHD and Parkinson's disease.
Scientists focused on dopamine neurons of the substantia nigra, an area responsible for motor function; its damage is associated with serious neurological disorders. A comparison of data from patients with Parkinson's disease and the results of animal studies showed coordinated work of genes involved in the synthesis, storage and transmission of dopamine signals. Although the described mechanism does not completely restore the level of dopamine, its study opens up prospects for the development of new therapeutic approaches.
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