Scientists from the Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences in Pushchino and Saratov University have presented innovative nanoparticles based on cerium oxide. They are capable of increasing the effectiveness of radiation therapy in cancer treatment.
The created nanoparticles are biocompatible and capable of participating in redox reactions. This is what allows protecting healthy cells from damage during irradiation.
A key aspect of the new approach is the modification of cerium oxide with pyrroloquinoline quinone — a molecule with an antioxidant effect that helps regulate the functioning of mitochondria. Experiments have shown that the use of nanoparticles during irradiation increased the survival rate of healthy cells by 45% compared to the control group. At the same time, the survival rate of cancer cells remained low, similar to the results of conventional radiation therapy.
The development opens up new prospects for improving cancer treatment methods, minimizing side effects and improving the quality of life of patients.
Earlier www1.ru reported that the only Russian drug against cancer based on a virus passed the first tests.
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