At Belgorod State University (BelSU), an innovative coating has been created for endobiliary stents used in the treatment of complications of gallstone disease. The new composition, based on methylcellulose and chlorhexidine bigluconate, eliminates the risk of allergic reactions and bacterial complications characteristic of iodine-containing analogs.
Stenting of the bile ducts is a standard procedure for mechanical jaundice and cholangitis. However, most modern stents contain iodine, which can cause allergies, and is also contraindicated in patients with thyroid diseases. In addition, over time, a protein film forms on the surface of the stents, promoting the growth of bacteria and inflammation.
The development of Belgorod scientists solves these problems. Methylcellulose ensures biocompatibility, and chlorhexidine bigluconate inhibits the growth of bacteria. As Professor Andrey Yarosh, the project leader, explained:
The method of applying a hypoallergenic antiseptic coating that we have proposed is simple and can be mastered at medical industry enterprises. And drainage of the common bile duct in patients with purulent cholangitis using a stent, which has been pre-coated with such a coating, is possible in any hospital equipped with endoscopic equipment and having qualified staff.
Clinical trials at the Belgorod Regional Hospital confirmed the effectiveness of the technology. The coating reduces bacterial colonization and prevents the deposition of calcium salts, extending the service life of the stent.
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