A test system for assessing the toxicity of cell therapy drugs has been created at Kazan Federal University (KFU). This was reported in the press service of the Ministry of Education and Science of the Russian Federation.
The new development will reduce the cost of preclinical and clinical studies of CAR-T drugs (intended for the treatment of oncological diseases) and increase their safety.
KFU scientists have suggested that cellular systems consisting of several types of cells have great potential as models for assessing toxicity. The study participants presented evidence that multicomponent tumor-stromal spheroids (CSS) can serve as an effective model for studying CAR-T mediated toxicity.
It is worth noting that in most preclinical studies, cultures of tumor cells are used as target cells for CAR-T cells. But toxicity is formed as a result of interaction with other patient cells (stromal, endothelial and immune). This leads to the fact that assessing toxicity based on a culture of one type of cell becomes impossible.
After that, studies are carried out on laboratory mice, but the immunology of humans and mice differs significantly. As a result, we receive the main data on the toxicity of drugs only during clinical trials.
Earlier www1.ru reported that scientists from the Tomsk National Research Medical Center, using spatial transcriptomics, investigated tongue cancer.
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