Tomsk Polytechnic University (TPU) has presented its achievements in the field of regenerative medicine, having developed non-toxic, lead-free nanoparticles that promote accelerated tissue regeneration.
Physicists and materials scientists at TPU, in collaboration with an international research group, have synthesized nanodevices that effectively convert magnetic fields into electrical signals, which activates cell growth. Leading researcher at the center "Piezo- and Magnetoelectric Materials" at TPU, Roman Chernozem, explained that this approach creates lead-free magnetoelectric nanostructures with a thin shell that respond to weak magnetic fields.
The particles, when inside cells, convert external magnetic fields into electrical signals, which stimulates stem cells. Testing of the nanoparticles under the influence of different magnetic fields demonstrated their biocompatibility and ability to help cells develop without apparent toxic effects. Under the influence of a magnetic field, there is an increase in the production of bone growth and mineralization markers, as well as activation of signaling pathways associated with integrin mechanosignaling.
Director of the research center "Piezo- and Magnetoelectric Materials" at TPU, Roman Surmenev, also commented on the study.
The issue of postoperative tissue regeneration is extremely acute for the treatment of cancer patients. In the future, we plan to conduct in vivo studies of the synthesized nanoparticles to assess their safety and effectiveness for activating targeted regeneration of various types of tissues, such as nerve tissue.
The study involved scientists from Russia and Portugal. The project received funding under a grant from the Ministry of Education and Science of Russia.
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