Chemists from Tomsk Polytechnic University (TPU) have synthesized new organic compounds that have demonstrated significant activity against orthopoxviruses, including the smallpox virus. The new substances have low toxicity and have shown high efficacy on cell lines, according to the university's press service.
TPU scientists, as part of a scientific collaboration, synthesized new organic compounds based on oxadiazolones, which can act as highly effective anti-orthopoxvirus agents. The new substances showed activity against the vaccinia virus, cowpox virus, ectromelia virus, and variola virus
Experimental studies and molecular modeling have shown that these substances are active in the late stages of the viral cycle and can affect the p37 protein, which is important for the formation of viral envelopes, helping to stop the development of viral infection.
According to Natalia Soldatova, Head of the International Research Laboratory "Non-covalent Interactions in the Chemistry of Materials" at TPU, the data obtained indicate that the synthesized compounds have become a promising basis for the development of broad-spectrum drugs against orthopoxviruses.
Read more materials:
Now on home
Start of deliveries scheduled for 2027
Over 51,000 new motorcycles were sold in Russia in 2025
The car will take at least a year to assemble
The application's audience has reached 20 million users
The model will be included in the list of cars for taxis, price - from 2.25 million rubles
All parking lots of the "Administrator of the Moscow Parking Space" are connected to the service
The cars will be supplied to the Moscow Transport Service Directorate
Deliveries to India may begin in 2028
The technology provides automated search for all types of defects in power units
The plane flew 500 km, accelerating to 425 km/h
The plant stated that the information about the termination of purchases for models 6 and 8 is not true
Scientists are using the "Ekran-M" installation