Chemists at Tomsk Polytechnic University (TPU) have synthesized new organic compounds that have demonstrated significant activity against orthopoxviruses, including variola viruses. The new substances have low toxicity and have shown high efficacy on cell lines, according to the university's press service.
TPU scientists, as part of a scientific collaboration, synthesized new organic compounds based on oxadiazolones, which can act as highly effective anti-orthopoxvirus agents. The new substances showed activity against the vaccinia virus, cowpox virus, ectromelia virus, and variola virus
Experimental studies and molecular modeling have shown that these substances are active in the late stages of the viral cycle and can affect the p37 protein, which is important for the formation of viral envelopes, helping to stop the development of viral infection.
According to Natalia Soldatova, Head of the International Research Laboratory "Non-covalent Interactions in Materials Chemistry" at TPU, the data obtained indicate that the synthesized compounds have become a promising basis for the development of broad-spectrum drugs against orthopoxviruses.
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