A Russian drug with silver nanoparticles, developed by scientists from Tomsk Polytechnic University (TPU) in collaboration with Mexican and Novosibirsk colleagues, has demonstrated high efficacy in treating infections in cows.
In a recent study, the drug "Argovit-S AgNP" proved more effective in combating bacterial biofilms than a popular foreign antibiotic.
Subclinical mastitis is an inflammation of the udder tissues in cows, affecting only small areas of the mammary gland. This condition often has no pronounced clinical signs, making it difficult to diagnose at an early stage. Nevertheless, it leads to a decrease in milk quality, as its composition deteriorates and the risk of bacterial contamination increases.
The drug was tested on dairy cows with subclinical mastitis in the Novosibirsk region. The herd was divided into two groups of 350 animals each. One group was given a foreign antibiotic (its name is not specified), the other group was given the drug "Argovit-S AgNP". Therapy was administered intramammarily until complete recovery, as determined by daily biochemical tests. Milk samples before and after treatment were analyzed to assess efficacy.
The results showed that treatment with the silver nanoparticle drug significantly reduced biofilm formation activity by 20.4% and the number of isolates with strong biofilms by 35.6%. The use of a foreign antibiotic showed the opposite results.
The study is the first large-scale translational study of the effect of silver nanoparticles on biofilm formation in animals and could be an important step in the fight against antibiotic resistance.
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