Scientists at the Sirius University of Science and Technology have developed a biocarcase for restoring the human spinal cord after injuries. This was reported by the press service of FT Sirius.
New polymer frameworks can become the basis for implants used in the therapy of spinal cord injuries. They, in combination with cell therapy, will create favorable conditions for nerve tissue regeneration.
Spinal cord injury remains one of the most complex medical problems due to the extremely limited regenerative potential of the central nervous system of an adult.
Laboratory tests of the framework showed that the density of neurons increases fivefold, creating a favorable environment for their growth.
The basis of the material for the biocarcase was a mixture of two biodegradable and biocompatible polymers — polylactide (PLA) and polycaprolactone (PCL). From the resulting mixture, a network of fibers was created using electrospinning, mimicking the extracellular matrix.
In our work, we have shown that not only the composition of the polymer, but also the porosity of the fiber surface critically affects neurons and astrocytes. By controlling the mechanics, architecture, and composition of the material, it is possible to create a more favorable environment for cells.
The next stage of development is research on animal models to assess functional recovery and integration of the implant with the tissue. Specialists also plan to modify the surfaces of the frameworks with neurotrophic factors to enhance their regenerative potential.