Russian scientists have created an accurate sensor to determine the level of anthracycline drugs in biological materials. This tool will help doctors select the optimal chemotherapy dose for each patient, according to the press service of the Russian Science Foundation (RSF).
The sensor we have developed is easy to use and allows analysis without complex equipment, which is important for medical diagnostics. It will allow doctors to quickly adjust the dose of anticancer drugs in the treatment of oncological diseases and reduce the risk of complications.
Scientists emphasize that anticancer drugs based on anthracyclines are effective but have serious side effects. Large doses of these drugs can lead to heart failure and other circulatory problems.
Today, it is difficult for doctors to select the optimal dose of drugs due to the complexity and high cost of methods for determining the concentration of anthracyclines in the body. For example, liquid chromatography is required. But Russian scientists have created a sensor that solves this problem with minimal costs. The device allows you to effectively control the dosage, saving resources of medical institutions.
Scientists have created a sensor based on a composite material made of graphene oxide and a polyproflavine dye. This material is capable of interacting with DNA. The researchers applied DNA molecules to the electrodes, which can bind to various anthracycline drugs. When these molecules come into contact with DNA chains, the electrical characteristics of the electrodes change significantly. This makes it possible to detect the presence of drugs in samples.
Earlier, Russian scientists created a unique installation for the treatment of the most complex types of cancer, including glioblastoma (an aggressive brain tumor). It was specifically designed to achieve maximum concentration of epithermal neutrons, minimizing the number of fast and thermal neutrons, which makes the treatment more accurate and safer.
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