Russian specialists have developed an innovative method for delivering drugs to the brain through the olfactory nerves. The technology uses magnetic nanoparticles and aromatherapy, providing a sixfold increase in efficiency compared to intravenous drug administration. The development will help in the treatment of brain tumors.
Scientists at Tomsk Polytechnic University have created a system for targeted delivery of drugs to brain tumors using magnetic nanoparticles. The principle is based on the natural mechanism of olfaction: substances penetrate the brain through the olfactory nerves, bypassing the blood-brain barrier.
We have developed containers made of magnetic nanoparticles that deliver drugs precisely to the address and preserve their integrity.
Aerosol of acetophenone with a sweet bird cherry scent proved to be particularly effective. Nanoparticles concentrate specifically in the tumor area, without spreading throughout the brain. This opens up new opportunities for the treatment of cancer, Parkinson's disease, and dementia.
Specialists from TPU, FIC Institute of Cytology and Genetics SB RAS, Institute of Catalysis, and Institute of Chemical Kinetics participated in the development. The results are published in the journal ACS Applied Nano Materials.
The technology has successfully passed preclinical trials and may become a new standard in the treatment of brain diseases.
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