Scientists from MIPT have developed special molds for growing cells intended for knee joints. The molds are based on two-component cast silicone.
The development was made possible through collaboration with specialists from the Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences. Molds were created for forming spheroids. These are three-dimensional cell structures. They help patients recover after knee replacement surgeries.
The developed solution allows creating three-dimensional cell structures not only in standard culture vessels, but also in rare modifications, such as multi-well plates and dishes for confocal microscopy.
The team used 3D modeling and a 3D printer to manufacture stamps and molds for spheroids. The uniqueness of this technological approach lies in the development of stamps for multi-well plates. This allows for effective testing of each patient.
Spheroids are introduced into the damaged area of the cartilage. In the body, they begin to release biologically active substances. This regenerates tissue and promotes the growth of cartilage cells.
The project to create molds and stamps for three-dimensional cell structures became a participant in the "Student Startup" competition at MIPT and received a grant of 1 million rubles from the federal Foundation for Assistance to Innovations.
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