Doctors at Penza State University are developing a module for a medical information system based on a unique algorithm that can identify the risk of developing breast cancer at an early stage. The development is being carried out as part of the "Rector's Grants of PSU" program and is intended for implementation in the regional "Promed" system.
According to the university, scientists have established a relationship between thyroid diseases and pathological changes in the mammary gland. Disorders in the endocrine system affect the level of the Ki-67 protein and specific receptors associated with the hormones estrogen and progesterone. These indicators are considered early markers of tumor processes.
The research team analyzed the medical histories of 120 patients from Penza and the region with diagnoses related to thyroid pathologies and breast cancer. In most cases, specialists identified a pattern: with a prolonged increase in the T4 hormone, even before the diagnosis, there was an increase in the activity of the Ki-67 protein, which is responsible for the reproduction of tumor cells. Based on these data, an algorithm has been created that can predict the risk of a malignant process.
The new module for the "Promed" system will automatically analyze the test results of patients at risk. If deviations are detected, the system will send a signal to the doctor about a possible threat, indicating which organ should be paid attention to. This will allow timely referral of patients for additional examination and adjustment of treatment.
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