The Institute of Chemistry of the Far Eastern Branch of the Russian Academy of Sciences (IC FEB RAS) has developed innovative bioactive coatings for 3D implants made of titanium and magnesium materials. These implants are designed for implantation in patients with complex fractures.
To speed up the healing process, a magnesium implant is implanted in the patient, the pores of the coating of which are used as containers for delivering bioactive substances. On top, they are covered with a dopamine film, which not only serves as a binder, but also promotes the formation of hydroxyapatite crystallization centers - the future bone tissue.
The use of 3D technologies allows personalizing implants taking into account the anatomical features of each patient. In the manufacturing process, not only titanium alloys are used, but also magnesium alloys (they have properties similar to bone tissue and can be absorbed in the body).
During research, we found that vitamin K2 is a more suitable candidate as an osteoinductor. Moreover, its use in coatings, especially together with zoledronic acid, has not yet been considered. We added vancomycin and got a more effective and cheaper option compared to foreign analogues of coatings for implants.
The development is undergoing preclinical trials; the absence of toxicity of the implants has already been proven. This year, scientists plan to begin research on fracture healing using new materials.
Earlier www1.ru reported that a new hydrogel material for wound treatment was created in St. Petersburg.
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